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Pharmacy Briefing - December 2025

5 December 2025
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Highlights

  • Evernorth announces transition to “transparent, rebate-free” pricing model
  • Federal government launches direct-to-consumer website TrumpRx
  • California passes Senate Bill 41, introduces new PBM regulations in the state

U.S. Food and Drug Administration (FDA) approvals and launches

  • Uzedy (long-acting risperidone) receives additional indication to treat Bipolar I disorder.
  • Jascayd (nerandomilast) is approved to treat idiopathic pulmonary fibrosis.
  • Libtayo (cemiplimab-rwlc) is approved as the first immunotherapy for adjuvant treatment of cutaneous squamous cell carcinoma, a type of skin cancer.
  • Rhapsido (remibrutinib) is approved to treat chronic spontaneous urticaria resistant to antihistamine treatment.

News

Evernorth announces transition to “transparent, rebate-free” pricing model

  • The pricing model will become the standard option available to all Evernorth’s pharmacy benefits clients, including self-funded clients, in 2028.
  • Evernorth also announced that its members will pay the lowest available cost for medicines, “whether it is the Evernorth negotiated price, their copay, or a cash discount price.”

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Federal government launches direct-to-consumer website TrumpRx

  • The website is currently non-operational but is listed as “coming soon in January 2026.”
  • According to the whitehouse.gov website, currently partnered manufacturers include Pfizer, AstraZeneca, and EMD Serono.

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California passes Senate Bill 41, introduces new PBM regulations in the state

  • The bill enacts several PBM regulations, including the prohibition of steerage toward PBM-affiliated pharmacies, the banning of spread pricing, and the negotiation of “exclusive arrangements with manufacturers.”
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Colorado becomes first state to cap the price of a prescription drug

  • The state set an upper payment limit for autoimmune drug Enbrel (etanercept) of $583.59 per unit for both government agencies and commercial plans that provide health insurance for state residents.
  • The effective date of the regulation is currently set for January 1, 2027.
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Manufacturers launch new wave of direct-to-consumer drug platforms

  • The AmgenNow program gives consumers access to cholesterol drug Repatha (evocolumab) at a monthly price of $239, touted as the lowest available price among economically developed countries.
  • Novartis and Boehringer Ingelheim are launching programs for Cosentyx (secukinumab) and Spiriva Respimat (tiotropium), respectively.
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Centers for Disease Control and Prevention (CDC) updates immunization guidelines

  • The updates pertain to COVID-19, chickenpox, and measles, mumps, and rubella vaccinations.
  • COVID-19 vaccinations currently do not require a prescription; a proposal to require a prescription was rejected by a narrow margin by the Advisory Committee on Immunization Practices.
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Fifteen states coordinate to form Governors Public Health Alliance

  • The Alliance’s purpose is to “strengthen emergency preparedness, improve communication, share data and expertise, and ensure states and territories can respond quickly and consistently to emerging health threats.”
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Pacific Business Group on Health (PBGH) launches Health Care Data Demonstration Project to promote transparency in drug pricing

  • The tools combine data from five large employers to estimate what a “fair price” for a drug or service should be compared to what an employer actually paid.
  • The group also published a white paper detailing key market price findings and data quality findings.
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Study finds significant cost differences between sites of care, health insurers across 13 common procedures

  • The study found that hospital outpatient departments were associated with 78% higher costs compared to ambulatory surgical centers.
  • The study also found wide variations in costs depending on insurer, even within identical sites of care.
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Study finds direct-to-consumer pharmacy associated with higher out-of-pocket costs but significantly lower overall costs

  • The study compared drug pricing from Mark Cuban Cost Plus Drug Company with pricing from several commercial insurance plans.
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